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Iran J Basic Med Sci. 2013 Nov;16(11):1119-32.

Pathogenesis of epilepsy: challenges in animal models.

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  • 1Faculty of Pharmacy, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Abstract

Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investigations have embarked on advancing knowledge of the mechanism underlying epileptogenesis, understanding in mechanism of pharmacoresistance and discovering antiepileptogenic or disease-modifying therapy. Animal models play a crucial and significant role in providing additional insight into mechanism of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways or processes. Hence, this article will discuss the known and postulated mechanisms of epileptogenesis and challenges in using the animal models.

KEYWORDS:

Animal models; Epileptogenesis; Pathogenesis of epilepsy; Temporal lobe epilepsy

PMID:
24494063
[PubMed]
PMCID:
PMC3909622
Free PMC Article

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