Format

Send to:

Choose Destination
See comment in PubMed Commons below
Saudi Pharm J. 2014 Jan;22(1):79-81. doi: 10.1016/j.jsps.2013.02.002. Epub 2013 Feb 14.

Interplay of biopharmaceutics, biopharmaceutics drug disposition and salivary excretion classification systems.

Author information

  • 1University of Petra, College of Pharmacy, Amman, Jordan.

Abstract

The aim of this commentary is to investigate the interplay of Biopharmaceutics Classification System (BCS), Biopharmaceutics Drug Disposition Classification System (BDDCS) and Salivary Excretion Classification System (SECS). BCS first classified drugs based on permeability and solubility for the purpose of predicting oral drug absorption. Then BDDCS linked permeability with hepatic metabolism and classified drugs based on metabolism and solubility for the purpose of predicting oral drug disposition. On the other hand, SECS classified drugs based on permeability and protein binding for the purpose of predicting the salivary excretion of drugs. The role of metabolism, rather than permeability, on salivary excretion is investigated and the results are not in agreement with BDDCS.

CONCLUSION:

The proposed Salivary Excretion Classification System (SECS) can be used as a guide for drug salivary excretion based on permeability (not metabolism) and protein binding.

KEYWORDS:

BCS; BDDCS; SECS

PMID:
24493977
[PubMed]
PMCID:
PMC3909751
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk