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Mol Biosyst. 2014 Apr;10(4):728-31. doi: 10.1039/c3mb70524b. Epub 2014 Jan 31.

Global gene expression distribution in non-cancerous complex diseases.

Author information

  • 1College of Bioinformatics Science and Technology, the Fourth Affiliated Hospital, Harbin Medical University, 157 Baojian Road, Harbin, China. wangdong@ems.hrbmu.edu.cn kongningli@hotmail.com zhuangliweiyd@126.com.


For gene expression in non-cancerous complex diseases, we systemically evaluated the sensitivities of biological discoveries to violation of the common normalization assumption. Our results indicated that gene expression may be widely up-regulated in digestive system and musculoskeletal diseases. However, global signal intensities showed little difference in other four disease types.

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