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Behav Neurol. 1991;4(2):103-11. doi: 10.3233/BEN-1991-4206.

Lack of selective vulnerability to anticholinergic induced cognitive impairment in early Parkinson's disease.

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  • 1Department of Neurology, UKRV, Spandauer Damm 130, Berlin 19, Germany.
  • 2University Hospital for Neurology, 6020 Innsbruck, Anichstr. 35, Austria.


Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphenidyl. Retesting after anticholinergic exposure (mean of 2 weeks for patients and 1 week for controls) revealed in young healthy controls the same pattern and magnitude of decline in memory function as in Parkinson patients. Non-demented subjects with Parkinson's disease of recent onset thus do riot seem to be selectively vulnerable to cognitive side-effects of anticholinergic treatment.

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