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Neuropharmacology. 2014 Jun;81:1-5. doi: 10.1016/j.neuropharm.2014.01.027. Epub 2014 Jan 29.

Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis.

Author information

  • 1Department of Neurology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85013, USA.
  • 2Department of Neuropathology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85013, USA.
  • 3Department of Neurology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ 85013, USA. Electronic address: jiong.shi@dignityhealth.org.

Abstract

Pertussis toxin (PTx) has various effects in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study was designed to explore the protective effects of PTx of different doses and subunits. EAE model was induced with myelin oligodendrocyte glycoprotein (MOG35-55, 200 ug) plus complete Freund's adjuvant in 6-7 week-old female C57BL/6 mice. PTx reduced clinical deficits of EAE by 91.3%. This reduction in clinical deficits was achieved by attenuating demyelination by 75.5%. Furthermore, PTx reduced the lymphocyte infiltration, deactivated microglia activation and changed T cell profile by increasing T helper (type 1 and 2) and T regulatory cells.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Experimental autoimmune encephalomyelitis; Microglia; Multiple sclerosis; Myelin oligodendrocyte glycoprotein; Pertussis toxin

[PubMed - indexed for MEDLINE]
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