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Cell. 2014 Jan 30;156(3):400-7. doi: 10.1016/j.cell.2013.12.028.

Progeria: a paradigm for translational medicine.

Author information

  • 1Department of Anesthesia, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Hasbro Children's Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02912, USA. Electronic address:
  • 2Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.
  • 3Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
  • 4National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:


Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have.

Copyright © 2014 Elsevier Inc. All rights reserved.

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