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Chem Commun (Camb). 2014 Mar 14;50(21):2762-4. doi: 10.1039/c3cc49771b.

Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening.

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  • 1Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Abstract

A novel multi-layer microfluidic device was developed for characterization of drug metabolism in human liver microsomes (HLMs) and their cytotoxicity on cells. The results demonstrated that this platform is robust for low levels of compounds and shows potential for high-throughput drug screening in drug development.

PMID:
24481240
[PubMed - indexed for MEDLINE]
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