Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biomaterials. 2014 Apr;35(11):3489-96. doi: 10.1016/j.biomaterials.2014.01.027. Epub 2014 Jan 26.

FRET-enabled biological characterization of polymeric micelles.

Author information

  • 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, USA.
  • 2David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA.
  • 3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, USA; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, USA. Electronic address: http://web.mit.edu/hammond/lab/

Abstract

Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo. FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Delivery; FRET; In vivo stability; Micelle; Self-assembly

PMID:
24477190
[PubMed - indexed for MEDLINE]
PMCID:
PMC4040354
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk