Treadmill running reduces parathyroid hormone concentrations during recovery compared with a nonexercising control group

J Clin Endocrinol Metab. 2014 May;99(5):1774-82. doi: 10.1210/jc.2013-3027. Epub 2014 Jan 29.

Abstract

Context: Lower PTH concentrations reported in the hours after acute, endurance exercise compared with preexercise levels might be influenced by factors such as circadian fluctuations.

Objective: The objective of the study was to compare postexercise PTH concentrations with a nonexercising control group.

Design and setting: A laboratory-based study with a crossover design, comparing a 60-minute (at 10:30 am) bout of treadmill running at 65% of the maximal rate of oxygen uptake (exercise) with semirecumbent rest (CON). Blood samples were obtained immediately before (baseline 10:15 am) and after (11:30 am) exercise and during recovery (12:30 am, 1:30 pm, and 2:15 pm).

Participants: Ten physically active men (mean ± 1 SD, age 26 ± 5 y; body mass 78.3 ± 5.8 kg; maximal rate of oxygen uptake 57.3 ± 6.9 mL/kg(-1) · min(-1)) participated in the study.

Main outcome measures: PTH, albumin-adjusted calcium, and phosphate concentrations were measured.

Results: PTH concentrations increased (+85%, P < .01) during exercise and were higher than in CON immediately at the end of exercise (4.5 ± 1.9 vs 2.6 ± 0.9 pmol/L(-1), P < .05). In the postexercise period (12:30-2:15 pm), PTH was not different compared with baseline but was lower compared with CON at 1:30 pm (-22%; P < .01) and tended to be lower at both 12:30 pm (-12%; P = .063) and 2:15 pm (-13%; P = .057). Exercise did not significantly affect the albumin-adjusted calcium concentrations, whereas phosphate was higher than CON immediately after exercise (1.47 ± 0.17 vs 1.03 ± 0.17 pmol/L(-1), P < .001) and was lower at 1:30 pm (-16%: P < .05).

Conclusions: Lower PTH concentrations after acute endurance running compared with a rested control condition suggest a true effect of exercise.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Over Studies
  • Exercise / physiology*
  • Humans
  • Male
  • Oxygen Consumption / physiology
  • Parathyroid Hormone / blood*
  • Running / physiology*

Substances

  • Parathyroid Hormone