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Galanin: a potent modulator of excitatory neurotransmission in the human urinary bladder.
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. GAL had an ED50 of 2 nM for the inhibition. The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. These data suggest a possible neuromodulator role of GAL in the human urinary bladder.
PMID: 2446889 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Potent contractile activity of endothelin on the human isolated urinary bladder.
Maggi CA, Giuliani S, Patacchini R, Santicioli P, Turini D, Barbanti G, Meli A.
Br J Pharmacol. 1989 Apr; 96(4):755-7.
[Br J Pharmacol. 1989]
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Prolonged inhibition of cardiac vagal action following sympathetic stimulation and galanin in anaesthetized cats.
Revington M, Potter EK, McCloskey DI.
J Physiol. 1990 Dec; 431:495-503.
[J Physiol. 1990]
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Effects of galanin, its analogues and fragments on rat isolated fundus strips.
Katsoulis S, Schmidt WE, Schwörer H, Creutzfeldt W.
Br J Pharmacol. 1990 Oct; 101(2):297-300.
[Br J Pharmacol. 1990]
Patient Drug Information
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Potassium (Glu-K® , K+ 10® , K+ 8® , ...)
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Hyoscyamine (Anaspaz® , Cystospaz® , Cystospaz-M® , ...)
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Darifenacin (Enablex, Urispas, Anaspaz, ...)
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