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    Eur J Pharmacol. 1987 Nov 3;143(1):135-7.

    Galanin: a potent modulator of excitatory neurotransmission in the human urinary bladder.

    Maggi CA, Santicioli P, Patacchini R, Turini D, Barbanti G, Beneforti P, Giuliani S, Meli A.

    Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.

    Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. GAL had an ED50 of 2 nM for the inhibition. The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. These data suggest a possible neuromodulator role of GAL in the human urinary bladder.

    PMID: 2446889 [PubMed - indexed for MEDLINE]

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