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J Integr Med. 2014 Jan;12(1):1-6. doi: 10.1016/S2095-4964(14)60008-X.

The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus.

Author information

  • 1Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
  • 2Department of Endocrinology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
  • 3Basic Medical Department, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
  • 4Department of Gerontology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
  • 5Department of Endocrinology, Shanghai East Hospital, Shanghai 200120, China.
  • 6Department of Police Training, Shanghai Police College, Shanghai 200137, China.
  • 7Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; E-mail:ligang.zhou@gmail.com.

Abstract

The central nervous system (CNS) plays a key regulatory role in glucose homeostasis. In particular, the brain is important in initiating and coordinating protective counterregulatory responses when blood glucose levels fall. This may due to the metabolic dependency of the CNS on glucose, and protection of food supply to the brain. In healthy subjects, blood glucose is normally maintained within a relatively narrow range. Hypoglycemia in diabetic patients can increase the risk of complications, such as heart disease and diabetic peripheral neuropathy. The clinical research finds that the use of traditional Chinese medicine (TCM) has a positive effect on the treatment of hypoglycemia. Here the authors reviewed the current understanding of sensing and counterregulatory responses to hypoglycemia, and discuss combining traditional Chinese and Western medicine and the theory of iatrogenic hypoglycemia in diabetes treatment. Furthermore, the authors clarify the feasibility of treating hypoglycemia on the basis of TCM theory and CNS and have an insight on its clinical practice.

PMID:
24461589
[PubMed - indexed for MEDLINE]
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