Abstract
Introduction:
Typhi is one of the rickettsial species endemic in the Mediterranean countries and is associated with the zoonotic infection of murine typhus, which may have a complicated course especially in adult patients. The association with macrophage activation syndrome (MAS) has rarely been reported in the medical literature.
Case report:
We describe a case of murine typhus in a diabetic woman complicated with MAS, who was effectively treated with cyclin and parenteral immunoglobulin.
Conclusion:
The murine typhus can be exceptionally complicated with SAM. This infection should be suspected in front of the discovery of SAM.
Keywords:
Cyclin; Cycline; Macrophage activation syndrome; Murine typhus; Syndrome d’activation macrophagique; Typhus murin.
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Anemia / etiology
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Anemia / therapy
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Antibodies, Bacterial / blood
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Blood Component Transfusion
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Diabetes Mellitus, Type 2 / complications
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Doxycycline / therapeutic use
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Drug Therapy, Combination
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Exanthema / etiology
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Female
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Fever / etiology
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Macrophage Activation*
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Middle Aged
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Retinitis / etiology
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Rickettsia typhi / immunology
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Syndrome
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Thrombocytopenia / etiology
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Thrombocytopenia / therapy
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Typhus, Endemic Flea-Borne / complications*
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Typhus, Endemic Flea-Borne / diagnosis
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Typhus, Endemic Flea-Borne / drug therapy
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Typhus, Endemic Flea-Borne / immunology
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Typhus, Endemic Flea-Borne / microbiology
Substances
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Adrenal Cortex Hormones
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Antibodies, Bacterial
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Immunoglobulins, Intravenous
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Doxycycline