Format

Send to:

Choose Destination
See comment in PubMed Commons below
ScientificWorldJournal. 2013 Dec 29;2013:294594. doi: 10.1155/2013/294594. eCollection 2013.

Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism.

Author information

  • 1Telehealth Center, National Taiwan University Hospital, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan ; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan.
  • 2Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan.
  • 3Department of Internal Medicine, Taoyuan General Hospital, Taoyuan 330, Taiwan.
  • 4Department of Laboratory Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.
  • 5Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan ; Department of Urology, Cleveland Clinic, Cleveland, OH 44011, USA.
  • 6Department of Internal Medicine, Postal Hospital, Taipei 100, Taiwan.
  • 7Internal Medicine, Buddhist Tzu Chi General Hospital, New Taipei City 231, Taiwan.
  • 8Institute of Pharmacology, National Taiwan University Medical College, Taipei 100, Taiwan.

Abstract

OBJECTIVE:

Primary aldosteronism (PA) is associated with inappropriate left ventricular hypertrophy (LVH) in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour urinary aldosterone level, plasma renin activity and aldosterone-to-renin ratio on this task.

METHODS:

We performed echocardiography in 106 patients with PA and 31 subjects with essential hypertension (EH) in a tertiary teaching hospital. Plasma renin activity, aldosterone concentration, and 24-hour urinary aldosterone level were measured.

RESULTS:

Only 24-hour urinary aldosterone was correlated with left ventricular mass index (LVMI) and excess LVMI among these parameters. The multivariate analysis revealed the urinary aldosterone level as an independent predictor for LVMI and excess LVMI. Analyzing the ability of urinary aldosterone, plasma aldosterone concentration, and plasma aldosterone-to-renin ratio to identify the presence of LVH (ROC AUC = 0.701, 0.568, 0.656, resp.) and the presence of inappropriate LV mass index (defined as measured LVMI in predicting LVMI ratio >135%) (ROC area under curve = 0.61, 0.43, 0.493, resp.) revealed the better performance of 24-hour urinary aldosterone.

CONCLUSIONS:

In conclusion, 24-hour urinary aldosterone level performed better to predict the presence of LVH and inappropriate LVMI in patients with PA.

PMID:
24459427
[PubMed - indexed for MEDLINE]
PMCID:
PMC3891226
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk