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Molecules. 2014 Jan 21;19(1):1344-52. doi: 10.3390/molecules19011344.

Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.

Author information

  • 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. daixuyong111@126.com.
  • 2Wuhan Biocause Pharmaceutical Development Co., Ltd, Wuhan 430056, Hubei, China. daixuyong111@126.com.
  • 3College of Chemical Engineering and Pharmacy, Jingchu University of Technology, Jingmen 448000, Hubei, China. jmliliwei@163.com.
  • 4Hubei Biocause Heilen Pharmaceutical Co., Ltd, Jingmen 448000, Hubei, China. wanqiong@biocause.net.
  • 5School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. maxwellcn@yahoo.com.
  • 6School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. champion88@163.com.

Abstract

Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm×4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.

PMID:
24451253
[PubMed - in process]
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