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Biochem Soc Trans. 2014 Feb;42(1):125-9. doi: 10.1042/BST20130203.

New strategies for the treatment of ovarian cancer.

Author information

  • 1*Institute for Science and Technology in Medicine and School of Pharmacy, Guy Hilton Research Centre, Keele University, Thornburrow Drive, Stoke-on-Trent, Staffordshire ST4 7QB, U.K.
  • 2‚ĆUniversity Hospital of North Staffordshire, Newcastle Road, Stoke-on-Trent, Staffordshire ST4 6QG, U.K.

Abstract

Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesis and PARP [poly(ADP-ribose) polymerase] inhibitors appear promising. Pre-clinical studies have identified several potential new therapeutic strategies, and we review the potential for use of BH3 (Bcl-2 homology) mimetics, autotaxin inhibitors and statins to treat ovarian cancer.

PMID:
24450639
[PubMed - indexed for MEDLINE]
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