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Metabolism. 2014 Apr;63(4):510-9. doi: 10.1016/j.metabol.2013.12.006. Epub 2013 Dec 14.

Multiple short bouts of exercise over 12-h period reduce glucose excursions more than an energy-matched single bout of exercise.

Author information

  • 1Department of Exercise Science, Syracuse University, Syracuse, NY, USA; Department of Exercise and Rehabilitative Sciences, Slippery Rock University, Slippery Rock, PA, USA.
  • 2School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia.
  • 3Department of Exercise Science, Syracuse University, Syracuse, NY, USA.
  • 4Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
  • 5Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA. Electronic address: kanaleyj@missouri.edu.

Abstract

OBJECTIVE:

Long, uninterrupted bouts of sedentary behavior are thought to negatively influence postprandial glucose and insulin concentrations. We examined the effects of a 1-h bout of morning exercise versus intermittent walking bouts of short duration on glucose excursions and insulin secretion over 12-h.

MATERIALS/METHODS:

Eleven young, obese individuals (18-35 years, BMI>30kg/m(2)) with impaired glucose tolerance were studied on three 12-h study days: 1) sedentary behavior (SED); 2) sedentary behavior with 1-h morning exercise (EX) at 60%-65% VO2peak; and 3) sedentary behavior with 12-hourly, 5-min intervals of exercise (INT) at 60%-65% VO2peak. Meals (1046kJ/meal) were provided every 2-h. Blood samples were collected every 10 min and measured for glucose, insulin, and c-peptide concentrations.

RESULTS:

Glucose iAUC (12-h) was attenuated in the INT and SED conditions compared to the EX condition (P<0.05). Glucose concentrations were higher in the EX compared to the SED condition for ~150min (20% of the study day), and comparison of the EX-INT study days revealed that glucose concentrations were greater for~240min (~1/3 of the 12-hday). In the SED condition, the 12-h insulin iAUC was ~15% higher (P<0.05) compared to the INT and EX conditions. Insulin production rate was found to increase ~20% with INT exercise vs. the SED and EX condition (P<0.05).

CONCLUSIONS:

Short, frequent periods of exercise attenuated glucose excursions and insulin concentrations in obese individuals to a greater degree than an equal amount of exercise performed continuously in the morning.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Glucose; Insulin; Obesity; Physical activity; Sedentary

PMID:
24439242
[PubMed - indexed for MEDLINE]
PMCID:
PMC3965589
Free PMC Article
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