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Molecules. 2014 Jan 10;19(1):819-25. doi: 10.3390/molecules19010819.

Pestalafuranones F-J, five new furanone analogues from the endophytic fungus Nigrospora sp. BM-2.

Author information

  • 1Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
  • 2Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China. d.zhangshuang@gmail.com.
  • 3Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China. kzou@ctgu.edu.cn.

Abstract

Five new 2(5H)-furanone-type derivatives, pestalafuranones F-J (compounds 3-7), together with two known compounds, pestalafuranones A (1) and B (2), were isolated from the ethyl acetate extract from the fermentation broth of the endophytic fungus Nigrospora sp. BM-2 in a hypersaline medium. The structures of these metabolites were elucidated by EIMS, HREIMS and NMR spectroscopic data. Compounds 1-7 exhibited no cytotoxic activities against the MDA-MB-231 and Caski cancer cell lines.

PMID:
24434694
[PubMed - in process]
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