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Circ Res. 1987 Oct;61(4 Pt 2):I6-9.

Neurotoxins that act selectively on voltage-dependent cardiac calcium channels.

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  • 1Department of Physiology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030.

Abstract

We searched for and found a toxin that acts specifically on cardiac calcium channels. This toxin, which we have designated TaiCatoxin (TCX), was purified from the venom of the Australian Taipan snake (Oxyuranus s. scutellatus), one of the world's most poisonous snakes. TCX is a highly charged, basic polypeptide with a molecular weight of 8,000. It blocks high- but not low-threshold cardiac calcium channels in a voltage-dependent manner and has no effect on potassium or sodium channels. The block occurs at nanomolar concentrations, is reversible, and is due to binding at an extracellularly facing site on the channel itself.

PMID:
2443275
[PubMed - indexed for MEDLINE]
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