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Sheng Wu Gong Cheng Xue Bao. 2013 Oct;29(10):1421-30.

[Advance in producing higher alcohols by microbial cell factories].

[Article in Chinese]

Author information

  • 1College of Bioscience and Bioengineering, Hebei University of Economics and Business, Shijiazhuang 050061, Hebei, China. liuzengran@163.com
  • 2College of Bioscience and Bioengineering, Hebei University of Economics and Business, Shijiazhuang 050061, Hebei, China.

Abstract

Higher alcohols have a high energy density, low hygroscopicity and can be mixed with gasoline at any ratio. It is the trend to replace fossil fuels with biofuels produced via microbial fermentation of renewable resources. We reviewed the progress in the development of engineered Saccharomyces cerevisiae and Escherichia coli that can produce higher alcohols, as well as the related technology platforms. We mainly focused on the construction of CoA-dependent pathways and alpha-keto acid mediated non-fermentative pathways, analyzed their respective characteristics, and summarized the construction strategies. The problems to be solved and future research direction were also discussed.

PMID:
24432657
[PubMed - in process]
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