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J Korean Med Sci. 2014 Jan;29(1):145-8. doi: 10.3346/jkms.2014.29.1.145. Epub 2013 Dec 26.

Localized thymic amyloidosis presenting with myasthenia gravis: case report.

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  • 1Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 2Department of Thoracic and Cardiovascular Surgery, Chungbuk National University College of Medicine, Cheongju, Korea.


A mediastinal mass was incidentally found on chest radiography in a 46-yr-old woman who had had myasthenia gravis (MG) for 2 months. Computed tomography revealed a 4-cm in size, well-defined, and lobulating mass with nodular calcification that was located in the thymus. Microscopically, the mass consisted of diffuse amorphous eosinophilic materials. These deposits exhibited apple-green birefringence under polarized light microscopy after Congo red staining. Immunohistochemical analysis revealed that they were positive for both kappa and lambda light chains and negative for amyloid A. A diagnosis of localized primary thymic amyloidosis was finally made. After thymectomy, the symptoms of MG were controlled with reduced corticosteroid requirements. Localized thymic amyloidosis associated with MG has not been reported to date.


Amyloidosis; Mediastinum; Myasthenia Gravis; Thymus

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