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Int J Clin Exp Pathol. 2013 Dec 15;7(1):394-401. eCollection 2014.

A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary.

Author information

  • 1Division of Pathology, Tokyo Rosai Hospital Tokyo, Japan ; Department of Human Pathology, Juntendo University School of Medicine Tokyo, Japan.
  • 2Department of Human Pathology, Juntendo University School of Medicine Tokyo, Japan.
  • 3Department of Gynecology, Juntendo University, Urayasu Hospital Chiba, Urayasu, Japan.

Abstract

We report a case of a 44-year-old woman with bilateral ovarian carcinoma that had metastasized from the colon and mimicked primary mucinous cystadenocarcinoma. Macroscopically, both ovarian tumors were large, multiloculated cystic masses with abundant mucinous content. Histologically, they were lined with mucinous epithelium with mild to moderate nuclear atypia and showed stromal invasion and surface involvement. At first, the tumors were diagnosed as bilateral primary ovarian mucinous cystadenocarcinomas. However, three months after surgery, a large villous tumor was discovered in the ascending colon by colonoscopic examination and was surgically resected. Histologically, the colonic tumor was a villous adenomatous tumor with invasive components of mucinous adenocarcinoma composed of well-differentiated adenocarcinoma and exhibited abundant extracellular mucin production. As a villous adenomatous component was present in the mucosal area, the colonic tumor was considered a primary tumor. Therefore, the original diagnosis of bilateral ovarian tumors was revised for consistent with metastasis from the colon carcinoma, in line with the findings of immunohistochemistry and loss of heterozygosity analysis. This case highlights the importance of considering the possibility of metastatic tumors from the gastrointestinal tract in the diagnosis of mucinous ovarian tumors.

KEYWORDS:

Krukenberg tumor; metastatic ovarian carcinoma; mucinous adenocarcinoma; mucinous cystadenocarcinoma

PMID:
24427362
PMCID:
PMC3885496
[PubMed - indexed for MEDLINE]
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