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J Clin Sleep Med. 2014 Jan 15;10(1):21-6. doi: 10.5664/jcsm.3350.

The effects of poor sleep quality on cognitive function of patients with cirrhosis.

Author information

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine University of Illinois at Chicago, Chicago, IL.
  • 2Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
  • 3Division of Biostatistics, Department of Health Sciences Research.

Erratum in

  • J Clin Sleep Med. 2014 Jul 15;10(7):823. Auger, Robert[corrected to Auger, Robert R].

Abstract

OBJECTIVES:

This study was conducted to assess the ill-defined relationship between sleep quality and multiple, specific domains of cognitive function in patients with cirrhosis.

METHODS:

A comprehensive battery of neuropsychological tests (divided into six neurocognitive domains) and a standardized, validated measure of sleep quality (Pittsburgh Sleep Quality Index [PSQI]) were administered to patients with cirrhosis and without evidence of overt hepatic encephalopathy, recruited from liver transplant and advanced liver disease clinics (n = 34). An inflammatory bowel disease (IBD) control group (n = 23) was similarly recruited and evaluated to control for the secondary effect of a chronic illness on cognition. PSQI global and component scores were used to predict cognitive function in each neurocognitive domain, using linear regression.

RESULTS:

Global PSQI scores were significantly higher (indicating poorer sleep quality) in the cirrhosis group (median [range] = 10 [1-19]) than in IBD controls = 5 (1-14); p = 0.002). After controlling for age and education, short duration of sleep was associated with impaired memory for patients with cirrhosis; the use of soporific agents was associated with poor visual-perceptual function in patients with IBD.

CONCLUSIONS:

Poor sleep was associated with worsening of the already impaired cognitive function of patients with cirrhosis.

KEYWORDS:

Minimal hepatic encephalopathy; cognitive impairment and cirrhosis; hepatic encephalopathy; poor sleep quality in cirrhosis

PMID:
24426816
[PubMed - indexed for MEDLINE]
PMCID:
PMC3869064
Free PMC Article
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