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Indian J Microbiol. 2014 Mar;54(1):114-7. doi: 10.1007/s12088-013-0438-4. Epub 2013 Nov 21.

Azithromycin Reduces the Production of α-hemolysin and Biofilm Formation in Staphylococcus aureus.

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  • 1Lishui People's Hospital, Lishui, 323000 China.
  • 2Department of Microbiology, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009 China.


Staphylococcus aureus causes a broad range of life-threatening diseases in humans. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases which are controlled by quorum sensing. In this study, we show that azithromycin was active against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranged from 32 to 64 μg/mL. Azithromycin at subinhibitory concentration, markedly reduced the production of α-hemolysin at (1/16MIC, 1/8MIC) and biofilm formation at (1/16MIC, 1/8MIC), respectively. The results indicated that sub-inhibitory concentrations of azithromycin decreased the production of α-hemolysin and biofilm formation in MRSA in a dose-dependent manner. Therefore, azithromycin may be useful in the treatment of α-hemolysin producing and biofilm formation MRSA infections.


Azithromycin; Biofilm; Staphylococcus aureus; α-hemolysin

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