Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cereb Cortex. 2015 Jun;25(6):1676-84. doi: 10.1093/cercor/bht425. Epub 2014 Jan 12.

Imaging patterns of brain development and their relationship to cognition.

Author information

  • 1Section of Biomedical Image Analysis, Department of Radiology, and Center for Biomedical Image Computing and Analytics.
  • 2Section of Biomedical Image Analysis, Department of Radiology, and Center for Biomedical Image Computing and Analytics Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • 3Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • 4Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

We present a brain development index (BDI) that concisely summarizes complex imaging patterns of structural brain maturation along a single dimension using a machine learning methodology. The brain was found to follow a remarkably consistent developmental trajectory in a sample of 621 subjects of ages 8-22 participating in the Philadelphia Neurodevelopmental Cohort, reflected by a cross-validated correlation coefficient between chronologic age and the BDI of r = 0.89. Critically, deviations from this trajectory related to cognitive performance. Specifically, subjects whose BDI was higher than their chronological age displayed significantly superior cognitive processing speed compared with subjects whose BDI was lower than their actual age. These results indicate that the multiparametric imaging patterns summarized by the BDI can accurately delineate trajectories of brain development and identify individuals with cognitive precocity or delay.

© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

KEYWORDS:

DTI; MRI; SVR; age prediction; brain development index

PMID:
24421175
[PubMed - in process]
PMCID:
PMC4428302
[Available on 2016-06-01]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk