Biochem Biophys Res Commun. 1987 Jul 31;146(2):666-71.

Human myelin DM-20 proteolipid protein deletion defined by cDNA sequence.

Abstract

Using a myelin proteolipid protein (PLP) cDNA as probe, a 1kb cDNA was isolated from a human retinal cDNA library. This clone, designated pDM-20, contained all of the coding sequence of PLP except for 105 base pairs which encode amino acids 117-151 of PLP. This deletion would result in a protein of the size of DM-20, the second major proteolipid of Central Nervous System (CNS) myelin. Homology between the DNA sequence at the 5' end of the deletion and the donor splicing consensus sequence suggests that PLP and DM-20 transcripts are derived from a single PLP gene by alternate splicing.

PMID:: 2441695; [PubMed - indexed for MEDLINE]

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Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin. [Proc Natl Acad Sci U S A. 1987]
Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin.
Nave KA, Lai C, Bloom FE, Milner RJ. Proc Natl Acad Sci U S A. 1987 Aug; 84(16):5665-9.
Individual exons encode the integral membrane domains of human myelin proteolipid protein. [Proc Natl Acad Sci U S A. 1986]
Individual exons encode the integral membrane domains of human myelin proteolipid protein.
Diehl HJ, Schaich M, Budzinski RM, Stoffel W. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9807-11.
Myelin proteolipid protein (PLP and DM-20) transcripts are deleted in jimpy mutant mice. [EMBO J. 1986]
Myelin proteolipid protein (PLP and DM-20) transcripts are deleted in jimpy mutant mice.
Morello D, Dautigny A, Pham-Dinh D, Jollès P. EMBO J. 1986 Dec 20; 5(13):3489-93.
Review The proteolipid protein gene. [Neuropathol Appl Neurobiol. 1995]
Review The proteolipid protein gene.
Griffiths IR, Montague P, Dickinson P. Neuropathol Appl Neurobiol. 1995 Apr; 21(2):85-96.
Review Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review. [Neurochem Res. 1994]
Review Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: a review.
Tuohy VK. Neurochem Res. 1994 Aug; 19(8):935-44.

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Cited by 1 PubMed Central article

A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. [J Cell Biol. 1993]
A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice.
Wight PA, Duchala CS, Readhead C, Macklin WB. J Cell Biol. 1993 Oct; 123(2):443-54.

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Human myelin DM-20 proteolipid protein deletion defined by cDNA sequence.
Human myelin DM-20 proteolipid protein deletion defined by cDNA sequence.
Biochem Biophys Res Commun. 1987 Jul 31 ;146(2):666-71.

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