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Glob Adv Health Med. 2013 Mar;2(2):26-31. doi: 10.7453/gahmj.2012.054.

Effectiveness of Platelet-rich Plasma Injection for Rotator Cuff Tendinopathy: A Prospective Open-label Study.

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  • 1Department of Orthopedics, Drexel University College of Medicine; Philadelphia, Pennsylvania, United States.
  • 2University of Wisconsin School of Medicine and Public Health, Department of Family Medicine, Madison, United States.
  • 3Department of Orthopedics, Drexel University College of Medicine; Philadelphia, Pennsylvania; United States.
  • 4Department of Orthopedic Surgery and Division of Sports Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania; Orthopedic Surgery, Drexel University College of Medicine, United States.
  • 5Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, United States.
  • 6Riverside Sports, Spine, and Fitness Center, Wintersville, Ohio, United States.
  • 7Departments of Family Medicine and Orthopedics, Division of Sports Medicine, Madison, Wisconsin, United States.
  • 8Images Interpretation Services, Ltd, and Open MRI of Steubenville and Weirton, Lifeline Hospital, Mingo Junction, Ohio, United States.


in English, Chinese, Spanish


Assess platelet rich plasma (PRP) injection for rotator cuff tendinopathy (RCT).


Prospective open label study with 1-year follow-up.


Participants recruited from an outpatient sports medicine clinic had clinically and magnetic resonance image (MRI)-demonstrated RCT refractory to physical therapy and corticosteroid injection. They received one ultrasound-guided injection of 3.0 mL of 1% xylocaine followed by 3.5 mL of PRP at the lesion and surrounding tendon.


0-10 visual analog scale (VAS; baseline, 8, 12, and 52 weeks).


functional shoulder tests assessing rotator cuff strength and endurance (at baseline and 8 and 12 weeks), MRI severity (1-5 points [at baseline and 4 and 8 weeks]), and patient satisfaction (52 weeks).


Eighteen participants with 19 assessed shoulders reported VAS pain score improvement from 7.5 ± 0.3 points to 0.5 ± 0.3 points by week 12 and 0.4 ± 0.2 (P = .0001) points at week 52. Functional outcomes significantly improved; the largest effect was seen in the external rotation test: 33.5 ± 5.7 seconds to 62.6 ± 7.2 seconds at week 12 (P = .0001). MRI appearance improved by 1 to 3 points in 16 of 18 assessed shoulders. Seventeen participants were "completely satisfied" (12) or "satisfied" (5). One participant was "unsatisfied."


A single ultrasound-guided, intralesional injection of PRP resulted in safe, significant, sustained improvement of pain, function, and MRI outcomes in participants with refractory RCT. Randomized multidisciplinary effectiveness trials that add ultrasound and validated clinical outcome measures are needed to further assess PRP for RCT.


PRP; Platelet rich plasma; rotator cuff tendinopathy

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