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Immunity. 2014 Jan 16;40(1):105-16. doi: 10.1016/j.immuni.2013.12.004. Epub 2014 Jan 9.

A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.

Author information

  • 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • 2Grupo de Inmunología Celular e Inmunogenética GICIG, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No.52-21, Medellin 05001000, Colombia.
  • 3Pediatric Infectious Diseases, Comer Children's Hospital, University of Chicago, Chicago, IL 60637, USA.
  • 4Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Millennium Institute on Immunology and Immunotherapy, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
  • 5National Institute of Mental Health and Neuroscience, Bangalore, Karnataka 560029, India.
  • 6Department of Chemistry and Medicinal Chemistry Programme, National University of Singapore, and Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A(∗)STAR), Biopolis 117543, Singapore.
  • 7Department of Chemistry and Biochemistry, Queens College of CUNY, Flushing, NY 11367, USA.
  • 8Faculty of Medicine, Cancer Sciences Academic Unit, University of Southampton, Southampton SO16 6YD, UK.
  • 9School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • 10School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • 11School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: g.besra@bham.ac.uk.
  • 12Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: steven.porcelli@einstein.yu.edu.

Abstract

Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells (iNKT cells). However, the question of which cells are the principal presenters of glycolipid antigens in vivo remains controversial, and it has been suggested that this might vary depending on the structure of a particular glycolipid antigen. Here we have shown that a single type of cell, the CD8α(+) DEC-205(+) dendritic cell, was mainly responsible for capturing and presenting a variety of different glycolipid antigens, including multiple forms of α-galactosylceramide that stimulate widely divergent cytokine responses. After glycolipid presentation, these dendritic cells rapidly altered their expression of various costimulatory and coinhibitory molecules in a manner that was dependent on the structure of the antigen. These findings show flexibility in the outcome of two-way communication between CD8α(+) dendritic cells and iNKT cells, providing a mechanism for biasing toward either proinflammatory or anti-inflammatory responses.

Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

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PMID:
24412610
[PubMed - indexed for MEDLINE]
PMCID:
PMC3895174
Free PMC Article
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