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Nature. 1987 Aug 13-19;328(6131):596-600.

A small catalytic oligoribonucleotide.


A 19-nucleotide RNA fragment can cause rapid, highly specific cleavage of a 24-nucleotide RNA fragment under physiological conditions. Because each 19-mer can participate in many cleavage reactions, this molecule has all the properties associated with an RNA enzyme.

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