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World J Surg Oncol. 2014 Jan 13;12:11. doi: 10.1186/1477-7819-12-11.

Soft tissue perineurioma of the tongue: report of a case and review of the literature.

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  • 1Department of Oral and Maxillofacial Surgery, The Medical School Hospital of Qingdao University, No, 1677, Wutaishan Road, Qingdao 266555, People's Republic of China.


Perineurioma is a rare benign tumor of the peripheral nervous system distinct from schwannomas and neurofibromas. It may be intraneural or extraneural (in the soft tissue). Extraneural soft tissue perineuriomas are uncommon; rare cases have been reported in the oral cavity. We present a case of soft tissue perineurioma in the tip of the tongue. The tumor was characterized by slender spindle cells, arranged in short fascicles or whorls, and focal areas showing a distinct storiform pattern. Tumor cells showed the immunohistochemical profile of perineurial cells, including epithelial membrane antigen. Smooth muscle actin, S-100, and CD34 were not expressed by the tumor cells. The tumor was surgically excised and in 2 years there has been no recurrence. Knowledge of the tumor in the oral cavity is important to reach a correct diagnosis and to avoid unnecessary aggressive local excision.

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