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PLoS Biol. 2014 Jan;12(1):e1001756. doi: 10.1371/journal.pbio.1001756. Epub 2014 Jan 7.

Two years later: journals are not yet enforcing the ARRIVE guidelines on reporting standards for pre-clinical animal studies.

Author information

  • 1Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • 2Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom ; Escola de Ciências da Saúde, Universidade do Minho, Braga, Portugal.
  • 3Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom ; Pathology Department, VU University Medical Centre, Amsterdam, The Netherlands.

Abstract

There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate into treatments for human disease. In 2010, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were introduced to help improve reporting standards. They were published in PLOS Biology and endorsed by funding agencies and publishers and their journals, including PLOS, Nature research journals, and other top-tier journals. Yet our analysis of papers published in PLOS and Nature journals indicates that there has been very little improvement in reporting standards since then. This suggests that authors, referees, and editors generally are ignoring guidelines, and the editorial endorsement is yet to be effectively implemented.

PMID:
24409096
[PubMed - indexed for MEDLINE]
PMCID:
PMC3883646
Free PMC Article
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