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J Biomed Opt. 2014 Jan;19(1):15006. doi: 10.1117/1.JBO.19.1.015006.

Deep-tissue light delivery via optrode arrays.

Author information

  • 1University of Utah, Department of Electrical and Computer Engineering, 36 Wasatch Dr., Salt Lake City, Utah 84112.
  • 2University of Utah, Department of Electrical and Computer Engineering, 36 Wasatch Dr., Salt Lake City, Utah 84112bUniversity of Utah, Department of Bioengineering, 50 S Central Campus Dr., Salt Lake City, Utah 84112.

Abstract

We establish performance characteristics of needle-type waveguides in three-dimensional array architectures as light delivery interfaces into deep tissue for applications, such as optogenetic and infrared (IR) neural stimulation. A single optrode waveguide achieves as high as 90% transmission efficiency, even at tissue depths >1  mm. Throughout the visible and near-IR spectrum, the effective light attenuation through the waveguide is ∼3 orders of magnitude smaller than attenuation in tissue/water, as confirmed by both simulation and experimental results. Light emission profiles from the optrode tips into tissue were also measured. Beam widths of 70 to 150 μm and full-angle divergence ranging from 13 to 40 deg in tissue can be achieved. These beam characteristics satisfy a wide range of requirements for targeted illumination in neural stimulation.

PMID:
24407529
[PubMed - indexed for MEDLINE]
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