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GMS Curr Top Otorhinolaryngol Head Neck Surg. 2013 Dec 13;12:Doc03. doi: 10.3205/cto000095.

Hazards and risks in oncology: radiation oncology.

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  • 1Department of Radiation Oncology, University Hospital Jena, Germany.


Adverse effects and hazards which have their origin from radiation using conventional techniques like 3-D conformal radiotherapy and total radiation doses are well known. However little is known about the sprectum of especially late toxicity after radiation using new technologies like intensity modulated radiotherapy (IMRT) combined with novel target volume and dose concepts. Since IMRT allows for selective protection of the large salivary glands this technique improves the intermediate term quality of life and is the standard of care despite many details need further prospective evaluation. Combining cytotoxic drugs and radiotherapy yield improved survival in well-defined high risk patients. However morbidity and mortality of these protocols are high and deserve special expertise and supportive therapy. EGF-receptor antibodies have gained well defined indications, albeit specific toxicities in combination with irradiation deserve prospective studies and special attention.


adverse events; chemoradiation; epidermal growth factor receptor; head and neck cancer; intensitiy modulated radiotherapy

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