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Angiology. 2015 Feb;66(2):169-73. doi: 10.1177/0003319713517927. Epub 2014 Jan 8.

Common variants of apolipoprotein E and cholesteryl ester transport protein genes in male patients with coronary heart disease and variable body mass index.

Author information

  • 1Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece genovefa@kolovou.com.
  • 2Department of Nutrition and Dietetic, Harokopio University, Athens, Greece.
  • 3Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
  • 4Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital campus, University College London Medical School, University College London (UCL), London, United Kingdom.
  • 5Thriasio Hospital, Elevsina, Greece.
  • 6Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
  • 7Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.

Abstract

Plasma lipids are major risk factors for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) and apolipoprotein (apo) E genes are involved in lipoprotein metabolism, thus affecting plasma lipid and lipoproteins levels. Furthermore, such polymorphisms have been associated with susceptibility to CHD and obesity. We evaluated the influence of the gene polymorphisms of CETP TaqIB (B1, B2) and I405V (V, I) and apo E (∊2,∊3,∊4) on lipid levels, according to body mass index (BMI) in Greek men with CHD. The TaqIB (B1, B2) polymorphism affected plasma low-density lipoprotein cholesterol levels in overweight men with CHD, whereas the I405V (V, I) polymorphism affected triglyceride concentrations in normal weight men. No correlation was found between BMI and apo E polymorphisms. Large prospective studies are required to investigate the relationships of CETP and apo E polymorphisms with lipids, BMI, and CHD susceptibility.

© The Author(s) 2014.

KEYWORDS:

apolipoprotein E; body mass index; cholesteryl ester transfer protein; gene polymorphisms; lipids; obesity

PMID:
24402318
[PubMed - indexed for MEDLINE]
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