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Vaccine. 2014 Feb 19;32(9):1079-85. doi: 10.1016/j.vaccine.2013.12.060. Epub 2014 Jan 4.

Human papillomavirus infection among human immunodeficiency virus-infected women in Maharashtra, India.

Author information

  • 1Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital Premises, 32 Sassoon Road, Pune 411001, India; Prayas Health Group, Amrita Clinic, Athwale Corner, Karve Road, Deccan Gymkhana, Pune, India.
  • 2Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram 695014, Kerala, India.
  • 3Prayas Health Group, Amrita Clinic, Athwale Corner, Karve Road, Deccan Gymkhana, Pune, India.
  • 4Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital Premises, 32 Sassoon Road, Pune 411001, India.
  • 5Screening Group (SCR), Early Detection & Prevention Section (EDP), International Agency for Research on Cancer (WHO-IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France.
  • 6Infections and Cancer Biology Group, Infections Section, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France.
  • 7Screening Group (SCR), Early Detection & Prevention Section (EDP), International Agency for Research on Cancer (WHO-IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. Electronic address: sankarr@iarc.fr.

Abstract

INTRODUCTION:

Frequency and distribution of HPV types in HIV-infected women with and without cervical neoplasia and their determinants have not been widely studied in India. We report and discuss HPV prevalence and type distribution in HIV-infected women.

METHODS:

HPV genotyping was done using cervical samples from 1109 HIV-infected women in a cross-sectional study.

RESULTS:

Any HPV was detected in 44.8% and high-risk ones in 41.0% women. Frequency of single and multiple high-risk infections were 26.7% and 14.3%, respectively. Frequencies of high-risk HPV infections in women with and without cervical neoplasia were 73.5% and 37.6%, respectively. HPV16 was the most common genotype, present in 11.5%, and 58.5% of women with cervical intraepithelial neoplasia (CIN) 2 and 3. Other most common high-risk HPV types in CIN 2-3 lesions were HPV 31 (22.6%); 56 (13.2%); 18 and 68a (11.3%) and 33, 35 and 51 (9.4%); and 70 (7.5%). Women under 30 or over 44 years, no abortions, and women with diagnosis of HIV infection within the last 5 years were at high risk of multiple oncogenic HPV infection.

CONCLUSION:

We observed a very high frequency of high-risk HPV and multiple infections in HIV-infected women.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Cervical cancer; Cervical intraepithelial neoplasia (CIN); Control; Human immunodeficiency virus (HIV); Human papillomavirus (HPV); Prevention; Screening

PMID:
24397900
[PubMed - indexed for MEDLINE]
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