Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Bioorg Khim. 2013 May-Jun;39(3):358-68.

Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections.

Author information

  • 1Department of Chemical Sciences, Suresh Gyan Vihar University, Jaipur. gnsharma2020@gmail.com
  • 2Department of Biotechnology and Food Science, Jayoti Vidyapeeth Women's University, Jaipur.
  • 3Anshu Dandia, Centre of Advanced Studies, Department of Chemistry, University of Rajasthan.
  • 4Department of Chemical Sciences, Suresh Gyan Vihar University, Jaipur.


An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-DHPs) incorporating 2-oxindole/piperidines is performed in 5-8 min with reasonable purity in 80-90% yield under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermatophytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment of dermatophytosis or ringworm infections.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk