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Gan To Kagaku Ryoho. 2013 Nov;40(12):2277-9.

[A case of gastric cancer with peritoneal metastasis successfully treated with multidisciplinary therapy].

[Article in Japanese]

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  • 1Dept. of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University.

Abstract

A 56-year-old woman with advanced gastric cancer with peritoneal metastasis was successfully treated with multidisciplinary therapy. Gastrectomy and total resection of the peritoneal metastasis were performed initially. Subsequently, combined chemotherapy with S-1/polysaccharide-Kureha( PSK) and intraperitoneal infusion( IP) of docetaxel( TXT) was continued for 9 months. Because of the appearance of hepatic metastasis, the anti -cancer drug was changed to irinotecan (CPT-11) that was administered by dropping intravenously( DIV therapy) and continued for 10 months. Despite the reduction of the hepatic metastasis, ascites was increased. All metastatic lesions disappeared after 3-months of paclitaxel (TXL) DIV therapy. Five years after the operation, the peritoneal metastasis recurred. Combined DIV and IP TXL therapy was administered for 2 months. The peritoneal metastasis was reduced and the TXL DIV therapy was continued for 6 months. Due to increased levels of tumor markers, capecitabine( Xeloda)/cisplatin( CDDP) was introduced; however, it could not be continued because of the side effects. Subsequent TXT DIV therapy was not effective; chemotherapy was switched to CPT-11 DIV therapy, which was effective for 14 months. S-1 and TXL IP therapy was initiated because of the appearance of a new peritoneal tumor. This therapy effectively controlled the disease until today. The patient is in good health at 8 years after the start of therapy.

PMID:
24394084
[PubMed - indexed for MEDLINE]
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