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J Neuroimmunol. 2014 Feb 15;267(1-2):97-101. doi: 10.1016/j.jneuroim.2013.12.011. Epub 2013 Dec 22.

Myasthenia gravis: predictive factors associated with the synchronized elevation of anti-acetylcholine receptor antibody titer in Kanazawa, Japan.

Author information

  • 1Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Electronic address: neuiwasa@med.kanazawa-u.ac.jp.
  • 2Health Service Center, Kanazawa University, Kanazawa, Japan.
  • 3Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
  • 4Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Abstract

For a brief period, an increased incidence of elevated anti-acetylcholine receptor antibody titer was observed in patients with myasthenia gravis (MG) in Kanazawa, Japan. The purpose of this study was to examine the predictive factors associated with this antibody titer elevation. Decreased odds of titer elevation were seen in patients with early-onset MG than in those with late-onset MG. In patients with non-thymoma-related MG, thymectomy prevented the antibody titer elevation. Our data suggest that late-onset MG may have a different immunogenic response and the thymus might play an immunoregulatory role against extrinsic factors in some types of MG.

Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

Anti-acetylcholine receptor antibody; Autoimmunity; Myasthenia gravis; Predictive factor

PMID:
24388223
[PubMed - indexed for MEDLINE]
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