Lignans from the aerial parts of Saururus chinensis: isolation, structural characterization, and their effects on platelet aggregation

Wei-Jern Tsai; Chien-Chang Shen; Tung-Hu Tsai; Lie-Chwen Lin

doi:10.1021/np400772h

Lignans from the aerial parts of Saururus chinensis: isolation, structural characterization, and their effects on platelet aggregation

J Nat Prod. 2014 Jan 24;77(1):125-31. doi: 10.1021/np400772h. Epub 2014 Jan 3.

Authors

Wei-Jern Tsai¹, Chien-Chang Shen, Tung-Hu Tsai, Lie-Chwen Lin

Affiliation

¹ National Research Institute of Chinese Medicine , Taipei, Taiwan.

PMID: 24387347
DOI: 10.1021/np400772h

Abstract

Five new diaryldimethylbutane lignans, saurulignans A-E (1-5), four new tetrahydrofuran lignans, saurufurins A-D (6-9), and one arylnaphthalene lignan, saurunarin (10), were isolated from Saururus chinensis, along with 18 known compounds. Lignan 5 showed significant inhibition of ADP-induced aggregation with an IC50 value of 9.8 μM and AA-induced aggregation with an IC50 value of 14.0 μM. Compound 19 showed significant activity to inhibit PAF-induced aggregation with an IC50 value of 9.1 μM. In addition, five isolated compounds could induce platelet aggregation. These results suggest that secondary metabolites in S. chinensis have bidirectional regulation on blood clotting and anticlotting effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Animals
Furans
Inhibitory Concentration 50
Lignans / chemistry
Lignans / isolation & purification*
Lignans / pharmacology*
Molecular Structure
Plant Roots / chemistry
Platelet Aggregation / drug effects*
Saururaceae / chemistry*
Taiwan

Substances

Furans
Lignans
tetrahydrofuran