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[Regulation of E-cadherin promoter activity by LMO2 impact on the progression and metastasis of prostate cancer].

[Article in Chinese]

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  • 1Medical College, Nankai University, Tianjin 300451, China.

Abstract

OBJECTIVE:

To study the abnormal expression of the proto-oncogene LMO2 affect the progression and metastasis mechanism of prostate cancer.

METHODS:

A series of reporter gene expression vectors carrying different lengths and point mutations of E-cadherin promoter were constructed. These plasmids were separately co-transfected with LMO2 into Lncap cells and the luciferase activity was detected after 24 h.

RESULTS:

The overexpression of LMO2 could significantly inhibit the activity of luciferase reporter gene of E-cadherin promoter about 50%. Truncated and point mutation study showed that this was mainly through E-box sites in the promoter region -204/-198.

CONCLUSION:

The proto-oncogene LMO2 can affect the progression and metastasis mechanism of prostate cancer by transcriptional inhibition of E-cadherin.

PMID:
24386807
[PubMed - indexed for MEDLINE]
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