Abstract
Superfusion of the excitatory amino acids glutamate (1-2 mM), quisqualate (15-30 microM) and N-methyl-D-aspartate (NMDA: 15-30 microM) induced inward currents in voltage-clamped motoneurones, in vitro. Typically the NMDA and quisqualate currents had prolonged time courses relative to glutamate currents. No desensitization was apparent during repeated agonist application. D-2-Amino-5-phosphonovalerate (10 microM) selectively antagonized the NMDA current without affecting the quisqualate current; the glutamate current was partially reduced reflecting its mixed agonist properties.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Amino-5-phosphonovalerate
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Amino Acids / pharmacology*
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Animals
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Anterior Horn Cells / drug effects*
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / pharmacology
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Glutamates / pharmacology
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Glutamic Acid
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In Vitro Techniques
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Ion Channels / drug effects*
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Membrane Potentials / drug effects
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Motor Neurons / drug effects*
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N-Methylaspartate
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Neural Conduction / drug effects
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Oxadiazoles / pharmacology
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Quisqualic Acid
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Rana temporaria
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Valine / analogs & derivatives
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Valine / pharmacology
Substances
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Amino Acids
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Glutamates
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Ion Channels
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Oxadiazoles
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Aspartic Acid
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Glutamic Acid
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N-Methylaspartate
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2-Amino-5-phosphonovalerate
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Quisqualic Acid
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Valine