Abstract
In this issue of Blood, Savchenko et al demonstrate that removal of neutrophil extracellular traps (NETs) and inhibition of neutrophil recruitment by DNase I with or without ADAMTS13 or inactivation of peptidyl arginine deiminase 4 (iPAD4) protects from cardiac damage after myocardial infarction in mice.
MeSH terms
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Animals
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Humans
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Hydrolases / genetics*
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Leukocytes / cytology*
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Male
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Myocardial Reperfusion Injury / pathology*
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Protein-Arginine Deiminase Type 4
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von Willebrand Factor / metabolism*
Substances
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von Willebrand Factor
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Hydrolases
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Protein-Arginine Deiminase Type 4
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peptidylarginine deiminase 4, mouse