DNase, ADAMTS13, and iPAD4: good for the heart

Blood. 2014 Jan 2;123(1):10-1. doi: 10.1182/blood-2013-11-538322.

Abstract

In this issue of Blood, Savchenko et al demonstrate that removal of neutrophil extracellular traps (NETs) and inhibition of neutrophil recruitment by DNase I with or without ADAMTS13 or inactivation of peptidyl arginine deiminase 4 (iPAD4) protects from cardiac damage after myocardial infarction in mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Hydrolases / genetics*
  • Leukocytes / cytology*
  • Male
  • Myocardial Reperfusion Injury / pathology*
  • Protein-Arginine Deiminase Type 4
  • von Willebrand Factor / metabolism*

Substances

  • von Willebrand Factor
  • Hydrolases
  • Protein-Arginine Deiminase Type 4
  • peptidylarginine deiminase 4, mouse