Format

Send to:

Choose Destination
See comment in PubMed Commons below
AIDS. 2013 Aug 24;27(13):2117-28. doi: 10.1097/QAD.0b013e328362395c.

Oral human papillomavirus infection in HIV-negative and HIV-infected MSM.

Author information

  • 1aCluster of Infectious Diseases, Public Health Service, Amsterdam bCentre for Infectious Disease Control, National Institute for Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu (RIVM)), Bilthoven cDepartment of Pathology, Vrije Universiteit-University Medical Center dDepartment of Internal Medicine, Jan van Goyen Medical Center eCenter for Infection and Immunity Amsterdam (CINIMA), Department of Internal Medicine, Academic Medical Center, Amsterdam fDepartment of Dermatology, Academic Medical Center, Amsterdam gDDL Diagnostic Laboratory, Rijswijk hJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. †Our inspiring colleague Hein Boot died before publication of this article.

Abstract

OBJECTIVE:

Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM.

DESIGN:

Analysis of baseline data from a prospective cohort study.

METHODS:

MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay [short PCR fragment (SPF)10-PCR-DNA Enzyme Immuno Assay (DEIA)/LiPA25 system].

RESULTS:

In 2010-2011, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years [interquartile range (IQR) 34.8-47.5] and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8 and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM.

CONCLUSION:

Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.

PMID:
24384590
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk