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Lancet Oncol. 2014 Jan;15(1):e33-41. doi: 10.1016/S1470-2045(13)70245-6.

Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review.

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  • 1National University Health System, Singapore, Singapore. Electronic address:
  • 2National University Health System, Singapore, Singapore.
  • 3National University Hospital, Singapore, Singapore.


Metastatic spine tumour surgery (MSTS) and metastatic musculoskeletal tumour surgery (MMTS) are associated with substantial blood loss. Allogeneic blood transfusion is the present method used to replenish this blood. Intraoperative cell salvage (IOCS) is a viable alternative, but is contraindicated in tumour surgery because of the risk of tumour dissemination. Use of IOCS-leucocyte depletion filter (LDF) allows removal of tumour cells from blood salvaged during oncological surgery. However, no reports exist on use of IOCS in MSTS or MMTS. We systematically reviewed studies on IOCS in oncological surgery to investigate whether sufficient evidence exists to support its use in MSTS or MMTS.

Copyright © 2014 Elsevier Ltd. All rights reserved.

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