Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2014 Jan;124(1):17-23. doi: 10.1172/JCI69740. Epub 2014 Jan 2.

Characterizing DNA methylation alterations from The Cancer Genome Atlas.

Abstract

The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.

PMID:
24382385
[PubMed - indexed for MEDLINE]
PMCID:
PMC3871233
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Clinical Investigation Icon for PubMed Central
    Loading ...
    Write to the Help Desk