Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Nucl Med Mol Imaging. 2013 Dec 15;4(1):53-9. eCollection 2013.

Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study.

Author information

  • 1Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
  • 2Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Nuclear Medicine Service, San Francisco Veterans Affairs Medical Center San Francisco, CA, USA.
  • 3Philips Healthcare San Jose, CA, USA.
  • 4Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Department of Radiotracer Development & Imaging Technology, Lawrence Berkeley National Laboratory Berkeley, CA, USA.

Abstract

Cardiac single photon emission computed tomography (SPECT) cameras typically rotate too slowly around a patient to capture changes in the blood pool activity distribution and provide accurate kinetic parameters. A spatiotemporal iterative reconstruction method to overcome these limitations was investigated. Dynamic rest/stress (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) SPECT/CT was performed along with reference standard rest/stress dynamic positron emission tomography (PET/CT) (13)N-NH3 in five patients. The SPECT data were reconstructed using conventional and spatiotemporal iterative reconstruction methods. The spatiotemporal reconstruction yielded improved image quality, defined here as a statistically significant (p<0.01) 50% contrast enhancement. We did not observe a statistically significant difference between the correlations of the conventional and spatiotemporal SPECT myocardial uptake K 1 values with PET K 1 values (r=0.25, 0.88, respectively) (p<0.17). These results indicate the clinical feasibility of quantitative, dynamic SPECT/CT using (99m)Tc-MIBI and warrant further investigation. Spatiotemporal reconstruction clearly provides an advantage over a conventional reconstruction in computing K 1.

KEYWORDS:

99mTc-MIBI; Dynamic SPECT; SPECT/CT; myocardial perfusion imaging; spatiotemporal reconstruction; uptake rate constant

PMID:
24380045
[PubMed]
PMCID:
PMC3867729
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk