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Front Immunol. 2013 Dec 16;4:424. doi: 10.3389/fimmu.2013.00424.

The lymph self-antigen repertoire.

Author information

  • 1Department of Pathology, Albert Einstein College of Medicine , New York, NY , USA ; Department of Microbiology and Immunology, Albert Einstein College of Medicine , New York, NY , USA.

Abstract

The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the "omic" composition of the tissue from which it originates in its physiological or pathological signature. Several recent proteomic analyses have mapped the proteome-degradome and peptidome of this immunologically relevant fluid pointing to the lymph as an important source of tissue-derived self-antigens. A vast array of lymph-circulating peptides have been mapped deriving from a variety of processing pathways including caspases, cathepsins, MMPs, ADAMs, kallikreins, calpains, and granzymes, among others. These self peptides can be directly loaded on circulatory dendritic cells and expand the self-antigenic repertoire available for central and peripheral tolerance.

KEYWORDS:

MHC class II; antigen presentation; antigen processing; lymph

PMID:
24379811
[PubMed]
PMCID:
PMC3864156
Free PMC Article
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