Abstract
Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa. The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP50 values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic
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Complement C1q / drug effects
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Complement C3 / drug effects
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Complement C5 / drug effects
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Complement C9 / drug effects
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Complement System Proteins / drug effects*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Gallic Acid / analogs & derivatives
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Molecular Structure
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Monoterpenes / chemistry
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Monoterpenes / isolation & purification*
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Monoterpenes / pharmacology*
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Paeonia / chemistry*
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Plant Bark / chemistry
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Plant Roots / chemistry
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Complement C3
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Complement C5
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Complement C9
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Drugs, Chinese Herbal
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Glucosides
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Monoterpenes
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galloylpaeoniflorin
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suffrupaeoniflorin A
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galloyloxypaeoniflorin
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Gallic Acid
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Complement C1q
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Complement System Proteins