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Ultrasound Obstet Gynecol. 2014 Jun;43(6):675-80. doi: 10.1002/uog.13289.

Thicknesses of individual layers of artery wall indicate increased cardiovascular risk in severe pre-eclampsia.

Author information

  • 1Department of Women's and Children's Health, Section for Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.

Abstract

OBJECTIVE:

To assess whether thicknesses of the intima and media in the common carotid artery (CCA) and the intima/media ratio (I/M) indicate an increased cardiovascular risk in non-pregnant women with a history of previous severe pre-eclampsia.

METHODS:

Thicknesses of the CCA intima and media layers were measured using non-invasive high-frequency (22 MHz) ultrasound in 42 women with a history of severe pre-eclampsia and 44 women with previous normal pregnancy.

RESULTS:

Women with a history of severe pre-eclampsia had a thicker CCA intima and a higher I/M than had women with previous normal pregnancy, also after adjustment for mean arterial pressure, body mass index and CCA intima-media thickness (IMT) (all P < 0.0001). CCA-IMT did not differ significantly between groups. In receiver-operating characteristics curve analysis, intima thickness and I/M clearly discriminated between women with and those without previous pre-eclampsia (area under the receiver-operating characteristics curve (AUC), 0.98 and 0.93), whereas CCA-IMT did not (AUC, 0.52).

CONCLUSIONS:

CCA individual intima and media thicknesses as well as I/M, but not CCA-IMT, reflect the known increased long-term cardiovascular risk of pre-eclampsia. Estimation of individual CCA layers using high-frequency ultrasound appears preferable to measuring CCA-IMT for investigating arterial effects and the increased cardiovascular risk in women with a history of severe pre-eclampsia.

Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.

KEYWORDS:

cardiovascular disease; high-frequency ultrasound; intima thickness; intima/media ratio; media thickness; pre-eclampsia

PMID:
24375803
[PubMed - in process]
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