Send to:

Choose Destination
See comment in PubMed Commons below
Head Neck. 2015 Feb;37(2):260-4. doi: 10.1002/hed.23587. Epub 2014 Apr 3.

Thyroid autoimmunity and risk of malignancy in thyroid nodules submitted to fine-needle aspiration cytology.

Author information

  • 1Department of Experimental Medicine, Unit of Endocrinology, "Sapienza" Università di Roma, Rome, Italy.



Whether the risk of cancer is increased in patients with chronic autoimmune thyroiditis is a controversial issue.


Between May 2005 and October 2012, 3777 fine-needle aspiration cytologies (FNACs) were performed on 2562 patients. Serum FT4, thyroid-stimulating hormone (TSH), anti-thyroglobulin antibody (TgAb), and anti-thyroperoxidase antibody (TPOAb) were determined.


Patients with suspicious cytology were younger and presented smaller maximum lesion diameter. In patients with TgAb positivity, suspicious cytology was detected more frequently (9.4%) than patients without TgAb (5.7%; p = .04). No significant difference was recorded between benign and suspicious cytology in the positive TPOAb rate. Risk factors for suspicious cytology were younger age (odds ratio [OR], 0.94), smaller maximum diameter (0.95), single lesion (1.85), microcalcifications (3.45), and TgAb (1.74). Mixed solid/fluid content resulted as being a protective factor (0.34). According to multivariate logistic regression analysis, age, mixed content, and microcalcification confirmed significance.


Thyroid nodule malignancy in patients with Hashimoto thyroiditis is not more frequent than in patients without thyroiditis.

© 2014 Wiley Periodicals, Inc.


Hashimoto disease; autoimmunity; biopsy; cytology; fine-needle aspiration cytology; thyroid neoplasms

[PubMed - in process]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk