Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pediatr Res. 2014 Apr;75(4):535-43. doi: 10.1038/pr.2013.250. Epub 2013 Dec 27.

Impact of breast-feeding and high- and low-protein formula on the metabolism and growth of infants from overweight and obese mothers.

Author information

  • 1Department of Molecular Biomarkers, Nestlé Institute of Health Sciences, Lausanne, Switzerland.
  • 2Department of Natural Bioactives and Screening, Nestlé Institute of Health Sciences, Lausanne, Switzerland.
  • 3Nestec, Nestle Research Center, Lausanne, Switzerland.
  • 4Department of Gynecology and Obstetrics, Faculty of Medicine, University of La Frontera, Temuco, Chile.
  • 51] Department of Molecular Biomarkers, Nestlé Institute of Health Sciences, Lausanne, Switzerland [2] Faculty of Life Sciences, E´cole Polytechnique Fédérale Lausanne (EPFL), Lausanne, Switzerland [3] Faculty of Sciences, Aarhus University, Aarhus, Denmark.
  • 6Department of Basic Sciences, Center for Genomics and Immunological Studies (Cegin), Faculty of Medicine, University of La Frontera, Temuco, Chile.
  • 7Nestec, Clinical Development Unit, Lausanne, Switzerland.

Abstract

BACKGROUND:

The combination of maternal obesity in early pregnancy and high protein intake in infant formula feeding might predispose to obesity risk in later life.

METHODS:

This study assesses the impact of breast- or formula-feeding (differing in protein content by 1.65 or 2.7 g/100 kcal) on the metabolism of term infants from overweight and obese mothers. From birth to 3 mo of age, infants received exclusively either breast- or starter formula-feeding and until 6 mo, exclusively either a formula designed for this study or breast-feeding. From 6 to 12 mo, infants received complementary weaning food. Metabonomics was conducted on the infants' urine and stool samples collected at the age of 3, 6, and 12 mo.

RESULTS:

Infant formula-feeding resulted in higher protein-derived short-chain fatty acids and amino acids in stools. Urine metabonomics revealed a relationship between bacterial processing of dietary proteins and host protein metabolism stimulated with increasing protein content in the formula. Moreover, formula-fed infants were metabolically different from breast-fed infants, at the level of lipid and energy metabolism (carnitines, ketone bodies, and Krebs cycle).

CONCLUSION:

Noninvasive urine and stool metabolic monitoring of responses to early nutrition provides relevant readouts to assess nutritional requirements for infants' growth.

PMID:
24375085
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk